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Issue Highlights page A27 Full Text | Full-Text PDF (33 KB)
Editorials
What Do Recent Studies on Lumpectomy Cavity Volume Change Imply for Breast Clinical Target Volumes? Leonard H. Kim, Frank Vicini, Di Yan pages 1-3 Full Text | Full-Text PDF (142 KB)
Understanding the Risk of Second Malignant Tumors in Children With Hodgkin's Disease Sarah S. Donaldson, Maureen M. O'Brien pages 4-5 Full Text | Full-Text PDF (61 KB)
Pain and Suffering During Cancer Therapy: Continued Sins of Omission Nora A. Janjan, Charles S. Cleeland pages 6-8 Full Text | Full-Text PDF (74 KB)
A Call to Action: Hospice and Palliative Medicine Board Certification Stephen T. Lutz pages 9-10 Full Text | Full-Text PDF (62 KB)
Controversy
Assessment of Technological Advances in Radiation Oncology: From Whence Comes the Funding? James D. Cox page 11 Full Text | Full-Text PDF (68 KB)
Hypofractionation, Long-Term Effects, and the Alpha/Beta Ratio Eli Glatstein pages 11-12 Full Text | Full-Text PDF (87 KB)
Balancing on a Knife's Edge: Evidence-Based Medicine and the Marketing of Health Technology Søren M. Bentzen, Todd H. Wasserman pages 12-14 Full Text | Full-Text PDF (92 KB)
CyberKnife Treatment of Prostate Cancer: A Reply to Bentzen and Wasserman Omar Dawood pages 14-18 Full Text | Full-Text PDF (112 KB)
Clinical Investigations
Brain
Long-Term Survival in Patients With Synchronous, Solitary Brain Metastasis From Non–Small-Cell Lung Cancer Treated With Radiosurgery, 15 February 2008 Todd W. Flannery, Mohan Suntharalingam, William F. Regine, Lawrence S. Chin, Mark J. Krasna, Michael K. Shehata, Martin J. Edelman, Marnie Kremer, Roy A. Patchell, Young Kwok pages 19-23 Abstract | Full Text | Full-Text PDF (177 KB)
Hodgkin's Disease
Subsequent Malignancies in Children Treated for Hodgkin's Disease: Associations With Gender and Radiation Dose Louis S. Constine, Nancy Tarbell, Melissa M. Hudson, Cindy Schwartz, Susan G. Fisher, Ann G. Muhs, Swati K. Basu, Larry E. Kun, Andrea Ng, Peter Mauch, Ajay Sandhu, Eva Culakova, Gary Lyman, Nancy Mendenhall pages 24-33 Abstract | Full Text | Full-Text PDF (413 KB)
Unilateral and Bilateral Breast Cancer in Women Surviving Pediatric Hodgkin's Disease Swati K. Basu, Cindy Schwartz, Susan G. Fisher, Melissa M. Hudson, Nancy Tarbell, Ann Muhs, Karen J. Marcus, Nancy Mendenhall, Peter Mauch, Larry E. Kun, Louis S. Constine pages 34-40 Abstract | Full Text | Full-Text PDF (210 KB)
Sarcoma
Impact of Local Management on Long-Term Outcomes in Ewing Tumors of the Pelvis and Sacral Bones: The University of Florida Experience, 30 January 2008 Daniel J. Indelicato, Sameer R. Keole, Amir H. Shahlaee, Wenyin Shi, Christopher G. Morris, C. Parker Gibbs, Mark T. Scarborough, Robert B. Marcus pages 41-48 Abstract | Full Text | Full-Text PDF (347 KB)
Breast
Magnetic Resonance Imaging Appearances in the Postoperative Breast: The Clinical Target Volume–Tumor and Its Relationship to the Chest Wall, 28 April 2008 Elisabeth C. Whipp, Michael Halliwell pages 49-57 Abstract | Full Text | Full-Text PDF (895 KB)
Prostate
Second Primary Cancer After Radiotherapy for Prostate Cancer—A SEER Analysis of Brachytherapy Versus External Beam Radiotherapy, 27 March 2008 May Abdel-Wahab, Isildinha M. Reis, Kara Hamilton pages 58-68 Abstract | Full Text | Full-Text PDF (273 KB)
Proposed Rectal Dose Constraints for Patients Undergoing Definitive Whole Pelvic Radiotherapy for Clinically Localized Prostate Cancer, 13 March 2008 Linda W. Chan, Ping Xia, Alexander R. Gottschalk, Michelle Akazawa, Matthew Scala, Barby Pickett, I-Chow Hsu, Joycelyn Speight, Mack Roach pages 69-77 Abstract | Full Text | Full-Text PDF (239 KB)
Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications After Carbon Ion Radiotherapy for Prostate Cancer, 06 May 2008 Hitoshi Ishikawa, Hiroshi Tsuji, Tadashi Kamada, Naoki Hirasawa, Takeshi Yanagi, Jun-Estu Mizoe, Koichiro Akakura, Hiroyoshi Suzuki, Jun Shimazaki, Takashi Nakano, Hirohiko Tsujii pages 78-84 Abstract | Full Text | Full-Text PDF (301 KB)
Hypofractionated Accelerated Radiotherapy Using Concomitant Intensity-Modulated Radiotherapy Boost Technique for Localized High-Risk Prostate Cancer: Acute Toxicity Results, 20 March 2008 Tee S. Lim, Patrick C.F. Cheung, D. Andrew Loblaw, Gerard Morton, Katharina E. Sixel, Geordi Pang, Parminder Basran, Liying Zhang, Romeo Tirona, Ewa Szumacher, Cyril Danjoux, Richard Choo, Gillian Thomas pages 85-92 Abstract | Full Text | Full-Text PDF (208 KB)
Lung
Bronchoscopic Implantation of a Novel Wireless Electromagnetic Transponder in the Canine Lung: A Feasibility Study, 04 April 2008 Martin L. Mayse, Parag J. Parikh, Kristen M. Lechleiter, Steven Dimmer, Mia Park, Amir Chaudhari, Michael Talcott, Daniel A. Low, Jeffrey D. Bradley pages 93-98 Abstract | Full Text | Full-Text PDF (862 KB)
Rectum
Prognostic Value of Pathologic Complete Response After Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Long-Term Analysis of 566 ypCR Patients, 14 April 2008 Carlo Capirci, Vincenzo Valentini, Luca Cionini, Antonino De Paoli, Claus Rodel, Robert Glynne-Jones, Claudio Coco, Mario Romano, Giovanna Mantello, Silvia Palazzi, Falchetti Osti Mattia, Maria Luisa Friso, Domenico Genovesi, Cristiana Vidali, Maria Antonietta Gambacorta, Alberto Buffoli, Marco Lupattelli, Maria Silvia Favretto, Giuseppe La Torre pages 99-107 Abstract | Full Text | Full-Text PDF (237 KB)
Phase I Study of Preoperative Radiation Therapy With Concurrent Infusional 5-Fluorouracil and Oxaliplatin Followed by Surgery and Postoperative 5-Fluorouracil Plus Leucovorin for T3/T4 Rectal Adenocarcinoma: ECOG E1297 David I. Rosenthal, Paul J. Catalano, Daniel G. Haller, Jerome C. Landry, Elin R. Sigurdson, Francis R. Spitz, Al B. Benson pages 108-113 Abstract | Full Text | Full-Text PDF (129 KB)
Anal Canal
Evaluation of Planned Treatment Breaks During Radiation Therapy for Anal Cancer: Update of RTOG 92-08, 09 May 2008 Andre Konski, Miguel Garcia, Madhu John, Richard Krieg, Wayne Pinover, Robert Myerson, Christopher Willett pages 114-118 Abstract | Full Text | Full-Text PDF (236 KB)
EXTRA—A Multicenter Phase II Study of Chemoradiation Using a 5 Day per Week Oral Regimen of Capecitabine and Intravenous Mitomycin C in Anal Cancer, 09 May 2008 Rob Glynne-Jones, Helen Meadows, Susan Wan, Simon Gollins, Martin Leslie, Ed Levine, Alec C. McDonald, Sun Myint, Les Samuel, David Sebag-Montefiore, National Cancer Research Institute Anal Sub Group and Colorectal Clinical Oncology Group pages 119-126 Abstract | Full Text | Full-Text PDF (386 KB)
Palliation
Internet-Based Survey Evaluating Use of Pain Medications and Attitudes of Radiation Oncology Patients Toward Pain Intervention, 10 June 2008 Charles B. Simone, Neha Vapiwala, Margaret K. Hampshire, James M. Metz pages 127-133 Abstract | Full Text | Full-Text PDF (661 KB)
Normal Tissue
Hyperbaric Oxygen Treatment of Chronic Refractory Radiation Proctitis: A Randomized and Controlled Double-Blind Crossover Trial With Long-Term Follow-Up, 13 March 2008 Richard E. Clarke, L. M. Catalina Tenorio, James R. Hussey, Akin S. Toklu, D. Lindsie Cone, Jose G. Hinojosa, Samir P. Desai, Luis Dominguez Parra, Sylvia D. Rodrigues, Robert J. Long, Margaret B. Walker pages 134-143.e15 Abstract | Full Text | Full-Text PDF (774 KB)
Radiation Oncology Practice
Japanese Structure Survey of Radiation Oncology in 2005 Based on Institutional Stratification of Patterns of Care Study, 27 March 2008 Teruki Teshima, Hodaka Numasaki, Hitoshi Shibuya, Masamichi Nishio, Hiroshi Ikeda, Hisao Ito, Kenji Sekiguchi, Norihiko Kamikonya, Masahiko Koizumi, Masao Tago, Yasushi Nagata, Hidekazu Masaki, Tetsuo Nishimura, Shogo Yamada, Japanese Society of Therapeutic Radiology and Oncology Database Committee pages 144-152 Abstract | Full Text | Full-Text PDF (234 KB)
Biology Contributions
Loss of Raf Kinase Inhibitory Protein Induces Radioresistance in Prostate Cancer Kathleen M. Woods Ignatoski, Navdeep K. Grewal, Sonja M. Markwart, Adaikkalam Vellaichamy, Arul M. Chinnaiyan, Kam Yeung, Michael E. Ray, Evan T. Keller pages 153-160 Abstract | Full Text | Full-Text PDF (844 KB)
Overexpression of Intrinsic Hypoxia Markers HIF1α and CA-IX Predict for Local Recurrence in Stage T1-T2 Glottic Laryngeal Carcinoma Treated With Radiotherapy M.L. Schrijvers, B.F.A.M. van der Laan, G.H. de Bock, W.J. Pattje, M.F. Mastik, L. Menkema, J.A. Langendijk, P.M. Kluin, E. Schuuring, J.E. van der Wal pages 161-169 Abstract | Full Text | Full-Text PDF (1803 KB)
Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol, 15 July 2008 Marjan Boerma, Kerrey A. Roberto, Martin Hauer-Jensen pages 170-177 Abstract | Full Text | Full-Text PDF (854 KB)
Increased But Error-Prone Nonhomologous End Joining in Immortalized Lymphoblastoid Cell Extracts From Adult Cancer Patients With Late Radionecrosis Wu-Meng Tan, Malcolm C. Paterson, Ghee Chong Koo, Hui Hua Li, Allan Price, Susan L.E. Loong pages 178-185 Abstract | Full Text | Full-Text PDF (276 KB)
Relative Biologic Effects of Low-Dose-Rate α-Emitting 227Th-Rituximab and β-Emitting 90Y-Tiuexetan-Ibritumomab Versus External Beam X-Radiation Jostein Dahle, Øyvind S. Bruland, Roy H. Larsen pages 186-192 Abstract | Full Text | Full-Text PDF (494 KB)
Engineered Modular Recombinant Transporters: Application of New Platform for Targeted Radiotherapeutic Agents to α-Particle Emitting 211At Andrey A. Rosenkranz, Ganesan Vaidyanathan, Oscar R. Pozzi, Vladimir G. Lunin, Michael R. Zalutsky, Alexander S. Sobolev pages 193-200 Abstract | Full Text | Full-Text PDF (344 KB)
Physics Contributions
Improving Soft-Tissue Contrast in Four-Dimensional Computed Tomography Images of Liver Cancer Patients Using a Deformable Image Registration Method He Wang, Sunil Krishnan, Xiaochun Wang, A. Sam Beddar, Tina M. Briere, Christopher H. Crane, Radhe Mohan, Lei Dong pages 201-209 Abstract | Full Text | Full-Text PDF (1384 KB)
Performance Evaluation of Automatic Anatomy Segmentation Algorithm on Repeat or Four-Dimensional Computed Tomography Images Using Deformable Image Registration Method He Wang, Adam S. Garden, Lifei Zhang, Xiong Wei, Anesa Ahamad, Deborah A. Kuban, Ritsuko Komaki, Jennifer O'Daniel, Yongbin Zhang, Radhe Mohan, Lei Dong pages 210-219 Abstract | Full Text | Full-Text PDF (3244 KB)
Feasibility of a Multigroup Deterministic Solution Method for Three-Dimensional Radiotherapy Dose Calculations Oleg N. Vassiliev, Todd A. Wareing, Ian M. Davis, John McGhee, Douglas Barnett, John L. Horton, Kent Gifford, Gregory Failla, Uwe Titt, Firas Mourtada pages 220-227 Abstract | Full Text | Full-Text PDF (1304 KB)
Risk of Developing Second Cancer From Neutron Dose in Proton Therapy as Function of Field Characteristics, Organ, and Patient Age, 19 June 2008 Christina Zacharatou Jarlskog, Harald Paganetti pages 228-235 Abstract | Full Text | Full-Text PDF (912 KB)
Intrafractional Motion of the Prostate During Hypofractionated Radiotherapy Yaoqin Xie, David Djajaputra, Christopher R. King, Sabbir Hossain, Lijun Ma, Lei Xing pages 236-246 Abstract | Full Text | Full-Text PDF (2419 KB)
Comparison of Dosimetric and Biologic Effective Dose Parameters for Prostate and Urethra Using 131Cs and 125I for Prostate Permanent Implant Brachytherapy Arjun Sahgal, Siavash Jabbari, Josephine Chen, Barbie Pickett, Mack Roach, Vivian Weinberg, I-Chow Hsu, Jean Pouliot pages 247-254 Abstract | Full Text | Full-Text PDF (881 KB)
Effect of Pretreatment Anemia on Treatment Outcome of Concurrent Radiochemotherapy in Patients With Head and Neck Cancer, 15 July 2008 André Fortin, Chang Shu Wang, Éric Vigneault pages 255-260 Abstract | Full Text | Full-Text PDF (398 KB)
Positioning Accuracy in Stereotactic Radiotherapy Using a Mask System With Added Vacuum Mouth Piece and Stereoscopic X-Ray Positioning Jan van Santvoort, Ruud Wiggenraad, Petra Bos pages 261-267 Abstract | Full Text | Full-Text PDF (652 KB)
Quantification and Visualization of Charged Particle Range Variations Shinichiro Mori, George T.Y. Chen pages 268-277 Abstract | Full Text | Full-Text PDF (1390 KB)
Four-Dimensional Computed Tomography–Based Treatment Planning for Intensity-Modulated Radiation Therapy and Proton Therapy for Distal Esophageal Cancer Xiaodong Zhang, Kuai-le Zhao, Thomas M. Guerrero, Sean E. Mcguire, Brian Yaremko, Ritsuko Komaki, James D. Cox, Zhouguang Hui, Yupeng Li, Wayne D. Newhauser, Radhe Mohan, Zhongxing Liao pages 278-287 Abstract | Full Text | Full-Text PDF (2037 KB)
Utility of Four-Dimensional Computed Tomography for Analysis of Intrafractional and Interfractional Variation in Lung Volumes Benjamin Rosen, George Starkschall, Keith Britton, Radhe Mohan, James D. Cox pages 288-294 Abstract | Full Text | Full-Text PDF (697 KB)
The Effect of Transponder Motion on the Accuracy of the Calypso Electromagnetic Localization System Martin J. Murphy, Richard Eidens, Edward Vertatschitsch, J. Nelson Wright pages 295-299 Abstract | Full Text | Full-Text PDF (399 KB)
Book Review
Review of Medical Effects of Ionizing Radiation Mark Little page 300 Full Text | Full-Text PDF (51 KB)
Letters to the Editor
In Regard to Fuller et al. Donald R. Royall page 301 Full Text | Full-Text PDF (81 KB)
Prone-Breast Radiotherapy: Too Early for Conclusions: In Regard to Chino et al. (Int J Radiat Oncol Biol Phys 2008;70:916–920) Stella C. Lymberis, Silvia C. Formenti pages 301-302 Full Text | Full-Text PDF (97 KB)
In Reply to Drs. Lymberis and Formenti Junzo Chino, Lawrence B. Marks page 302 Full Text | Full-Text PDF (62 KB)
Prone Positioning Causes the Heart to Be Displaced Anteriorly Within the Thorax: Implications for Breast Cancer Treatment Yukihiro Hama page 302 Full Text | Full-Text PDF (65 KB)
In Reply to Dr. Hama Junzo Chino, Lawrence Marks page 302 Full Text | Full-Text PDF (62 KB)
Radiobiologic Parameters and Local Effect Model Predictions for Head-and-Neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions: In Regard to Beuve et al. (Int J Radiat Oncol Biol Phys, In Press) Michael Scholz, Thilo Elsässer pages 302-303 Full Text | Full-Text PDF (88 KB)
In Response to Scholz et al. Michael Beuve, Claire Rodriguez-Lafrasse page 303 Full Text | Full-Text PDF (73 KB)
Contouring Carcinomas by FDG-PET: Is the Role of Tumor Biology Underestimated?: In Regard to MacManus et al. (Int J Radiat Oncol Biol Phys 2008;71:2–4) Paolo Farace, Mirco Galiè, Cristina Nanni, Antonello Spinelli, Stefano Fanti pages 303-304 Full Text | Full-Text PDF (91 KB)
In Reply to Dr. Faraci and Colleagues Michael P. MacManus, Rodney J. Hicks page 304 Full Text | Full-Text PDF (68 KB)
Radiation-Induced Malignant Gliomas: Is There a Role for Reirradiation?: In Regard to Paulino et al. (Int J Radiat Oncol Biol Phys Epub 2008 Feb 8) Amit Bahl, Daya N. Sharma, Milind Kumar, K.S.J. Basu, Gaura K. Rath pages 304-305 Full Text | Full-Text PDF (86 KB)
In Reply to Dr. Bahl and Colleagues Arnold C. Paulino page 305 Full Text | Full-Text PDF (66 KB)
Intraoperative Radiation Therapy After Radical Prostatectomy: In Regard to Saracino et al. (Int J Radiat Oncol Biol Phys, In Press) Barbara A. Jereczek-Fossa, Roberto Orecchia pages 305-306 Full Text | Full-Text PDF (82 KB)
In Response to Drs. Jereczek-Fossa and Orecchia Biancamaria Saracino page 306 Full Text | Full-Text PDF (58 KB)
Errata
Errata page 306 Full Text | Full-Text PDF (58 KB)
Errata page 307 Full Text | Full-Text PDF (137 KB)
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