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Issue Highlights
S. K. Yi, W. H. Hall, M. Mathai, A. B. Dublin, V. Gupta, J. A. Purdy, and A. M. Chen
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A4
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Oncology Scan - March 1, 2012
Dueñas-González A, Zarbá JJ, Patel F, et al. Phase III, Open-Label, Randomized Study Comparing Concurrent Gemcitabine Plus Cisplatin and Radiation Followed by Adjuvant Gemcitabine and Cisplatin Versus...
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Arno J. Mundt
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1039-1041
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| Editorial |
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Are the Results of RTOG 0617 Mysterious?
On June 17, 2011, two of the four arms in the Radiation Therapy Oncology Group (RTOG) 0617 protocol were closed to accrual when a planned interim analysis showed that the higher radiation dose being t...
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James D. Cox
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1042-1044
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| Critical Reviews |
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Adjuvant Versus Salvage Radiotherapy After Prostatectomy: The Apple Versus the Orange
The eradication of microscopic residual disease within the prostate bed after radical prostatectomy (RP) can potentially be achieved with the use of radiotherapy (RT) by two distinct strategies: in th...
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Christopher R. King
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1045-1046
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Radiotherapy for Liver Metastases: A Review of Evidence
Over the past decade, there has been an increasing use of radiotherapy (RT) for the treatment of liver metastases. Most often, ablative doses are delivered to focal liver metastases with the goal of l...
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Morten Høyer,
Anand Swaminath,
Sean Bydder,
Michael Lock,
Alejandra Méndez Romero,
Brian Kavanagh,
Karyn A. Goodman,
Paul Okunieff,
Laura A. Dawson
et al.
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1047-1057
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| Feature: Book Review |
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Clinical Fundamentals for Radiation Oncologists
Clinical Fundamentals for Radiation Oncologists, an updated and expanded version of Clinical Fundamentals for Radiation Oncology Residents (2006) based on Dr. Murshed’s preparation for the board exami...
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Kin-Sing Au
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e337
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| Letters to the Editor |
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In Regard to “Thymidylate Synthase Gene Polymorphism Affects the Response to Preoperative 5-Fluorouracil Chemoradiation Therapy in Patients With Rectal Cancer” (Int J Radiat Oncol Biol Phys 2011;81:669–676)
To the Editor: When preparing a manuscript addressing TS genetic polymorphisms in the context of neoadjuvant radiochemotherapy in patients with locally advanced rectal cancer, we read with great inter...
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Markus Anton Schirmer,
Hendrik Andreas Wolff,
Lena Christin Conradi,
Hans Christiansen
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1058
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In Regard to “Breast Cancer Recurrent on Supraclavicular Node(s): What Is the Treatment?” (Int J Radiat Oncol Biol Phys 2011;80:1453–1457)
To the Editor: In a recent issue of this journal, Reddy et al. reported encouraging overall survival data after isolated supraclavicular nodal recurrence (ISNR) in breast cancer patients previously s...
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Stefano Pergolizzi,
Anna Santacaterina
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1058-1059
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In Reply to Drs. Pergolizzi and Santacaterina
To the Editor: We appreciate the comments made by Drs. Pergolizzi and Santacaterina on our recent report on patient outcomes in the setting of isolated supraclavicular nodal (SCV) recurrence after mas...
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Jay P. Reddy,
Wendy A. Woodward
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1059
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| Clinical Investigations |
| Normal Tissue |
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Validating the RTOG-Endorsed Brachial Plexus Contouring Atlas: An Evaluation of Reproducibility Among Patients Treated by Intensity-Modulated Radiotherapy for Head-and-Neck Cancer
02 May 2011
Purpose: To evaluate interobserver variability for contouring the brachial plexus as an organ-at-risk (OAR) and to analyze its potential dosimetric consequences in patients treated with intensity-modu...
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Sun K. Yi,
William H. Hall,
Mathew Mathai,
Arthur B. Dublin,
Vishal Gupta,
James A. Purdy,
Allen M. Chen
et al.
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1060-1064
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Standardized Total Average Toxicity Score: A Scale- and Grade-Independent Measure of Late Radiotherapy Toxicity to Facilitate Pooling of Data From Different Studies
23 May 2011
Purpose: The search for clinical and biologic biomarkers associated with late radiotherapy toxicity is hindered by the use of multiple and different endpoints from a variety of scoring systems, hamper...
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Gillian C. Barnett,
Catharine M.L. West,
Charlotte E. Coles,
Paul D.P. Pharoah,
Christopher J. Talbot,
Rebecca M. Elliott,
George A. Tanteles,
R. Paul Symonds,
Jennifer S. Wilkinson,
Alison M. Dunning,
Neil G. Burnet,
Søren M. Bentzen
et al.
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1065-1074
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Effects of Irradiation on Brain Vasculature Using an In Situ Tumor Model
23 December 2011
Purpose: Damage to normal tissue is a limiting factor in clinical radiotherapy (RT). We tested the hypothesis that the presence of tumor alters the response of normal tissues to irradiation using a ra...
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Janice A. Zawaski,
M. Waleed Gaber,
Omaima M. Sabek,
Christy M. Wilson,
Christopher D. Duntsch,
Thomas E. Merchant
et al.
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1075-1082
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A Prolonged Time Interval Between Trauma and Prophylactic Radiation Therapy Significantly Increases the Risk of Heterotopic Ossification
21 October 2011
Purpose: To ascertain whether the time from injury to prophylactic radiation therapy (RT) influences the rate of heterotopic ossification (HO) after operative treatment of displaced acetabular fractur...
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Waleed F. Mourad,
Satyaseelan Packianathan,
Rania A. Shourbaji,
Zhen Zhang,
Mathew Graves,
Majid A. Khan,
Michael C. Baird,
George Russell,
Srinivasan Vijayakumar
et al.
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e339-e344
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| Head-and-Neck Cancers |
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Risk of Carotid Blowout After Reirradiation of the Head and Neck: A Systematic Review
06 May 2011
Purpose: Carotid blowout (CB) is a rare but frequently fatal complication of head-and-neck (H&N) cancer or its treatment. We sought to determine the reported rate of CB in patients receiving salva...
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Mark W. McDonald,
Michael G. Moore,
Peter A.S. Johnstone
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1083-1089
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Prognostic Value of Prevertebral Space Involvement in Nasopharyngeal Carcinoma Based on Intensity-Modulated Radiotherapy
23 August 2011
Purpose: To investigate the prognostic significance of prevertebral space involvement (PSI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). Method...
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Guan-qun Zhou,
Yan-Ping Mao,
Lei Chen,
Wen-Fei Li,
Li-Zhi Liu,
Ying Sun,
Yong Chen,
Li Tian,
Ai-Hua Lin,
Li Li,
Jun Ma
et al.
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1090-1097
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Diffusion-Weighted Magnetic Resonance Imaging Early After Chemoradiotherapy to Monitor Treatment Response in Head-and-Neck Squamous Cell Carcinoma
21 April 2011
Purpose: To evaluate diffusion-weighted imaging (DWI) for assessment of treatment response in head and neck squamous cell carcinoma (HNSCC) three weeks after the end of chemoradiotherapy (CRT). Method...
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Vincent Vandecaveye,
Piet Dirix,
Frederik De Keyzer,
Katya Op de Beeck,
Vincent Vander Poorten,
Esther Hauben,
Maarten Lambrecht,
Sandra Nuyts,
Robert Hermans
et al.
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1098-1107
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Treatment Planning Constraints to Avoid Xerostomia in Head-and-Neck Radiotherapy: An Independent Test of QUANTEC Criteria Using a Prospectively Collected Dataset
02 June 2011
Purpose: The severe reduction of salivary function (xerostomia) is a common complication after radiation therapy for head-and-neck cancer. Consequently, guidelines to ensure adequate function based on...
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Vitali Moiseenko,
Jonn Wu,
Allan Hovan,
Ziad Saleh,
Aditya Apte,
Joseph O. Deasy,
Stephen Harrow,
Carman Rabuka,
Adam Muggli,
Anna Thompson
et al.
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1108-1114
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Dynamic Contrast-Enhanced MRI in Head-and-Neck Cancer: The Impact of Region of Interest Selection on the Intra- and Interpatient Variability of Pharmacokinetic Parameters
10 October 2011
Purpose: Dynamic contrast–enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation...
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Oana I. Craciunescu,
David S. Yoo,
Esi Cleland,
Naira Muradyan,
Madeline D. Carroll,
James R. MacFall,
Daniel P. Barboriak,
David M. Brizel
et al.
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e345-e350
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Quantitation of Human Papillomavirus DNA in Plasma of Oropharyngeal Carcinoma Patients
10 October 2011
Purpose: To determine whether human papillomavirus (HPV) DNA can be detected in the plasma of patients with HPV-positive oropharyngeal carcinoma (OPC) and to monitor its temporal change during radioth...
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Hongbin Cao,
Alice Banh,
Shirley Kwok,
Xiaoli Shi,
Simon Wu,
Trevor Krakow,
Brian Khong,
Brindha Bavan,
Rajeev Bala,
Benjamin A. Pinsky,
Dimitrios Colevas,
Nader Pourmand,
Albert C. Koong,
Christina S. Kong,
Quynh-Thu Le
et al.
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e351-e358
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Baseline Serum Lactate Dehydrogenase Levels for Patients Treated With Intensity-Modulated Radiotherapy for Nasopharyngeal Carcinoma: A Predictor of Poor Prognosis and Subsequent Liver Metastasis
13 October 2011
Purpose: To evaluate the prognostic value of baseline serum lactate dehydrogenase (LDH) levels in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). Met...
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Guan-Qun Zhou,
Ling-Long Tang,
Yan-Ping Mao,
Lei Chen,
Wen-Fei Li,
Ying Sun,
Li-Zhi Liu,
Li Li,
Ai-Hua Lin,
Jun Ma
et al.
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e359-e365
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Prediction of Neck Dissection Requirement After Definitive Radiotherapy for Head-and-Neck Squamous Cell Carcinoma
Background: This analysis was undertaken to assess the need for planned neck dissection in patients with a complete response (CR) of involved nodes after irradiation and to determine the benefit of a ...
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Juliette Thariat,
K. Kian Ang,
Pamela K. Allen,
Anesa Ahamad,
Michelle D. Williams,
Jeffrey N. Myers,
Adel K. El-Naggar,
Lawrence E. Ginsberg,
David I. Rosenthal,
Bonnie S. Glisson,
William H. Morrison,
Randal S. Weber,
Adam S. Garden
et al.
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e367-e374
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Monitoring Dosimetric Impact of Weight Loss With Kilovoltage (KV) Cone Beam CT (CBCT) During Parotid-Sparing IMRT and Concurrent Chemotherapy
23 December 2011
Purpose: Parotid-sparing head-and-neck intensity-modulated radiotherapy (IMRT) can reduce long-term xerostomia. However, patients frequently experience weight loss and tumor shrinkage during treatment...
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Kean Fatt Ho,
Tom Marchant,
Chris Moore,
Gareth Webster,
Carl Rowbottom,
Hazel Penington,
Lip Lee,
Beng Yap,
Andrew Sykes,
Nick Slevin
et al.
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e375-e382
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| Lymphoma |
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Mild Toxicity and Favorable Prognosis of High–Dose and Extended Involved-Field Intensity-Modulated Radiotherapy for Patients With Early-Stage Nasal NK/T-Cell Lymphoma
21 April 2011
Purpose: The value of intensity-modulated radiotherapy (IMRT) for early-stage nasal NK/T-cell lymphoma has not been previously reported. The aim of the present study was to assess the dosimetric param...
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Hua Wang,
Ye-Xiong Li,
Wei-Hu Wang,
Jing Jin,
Jian-Rong Dai,
Shu-Lian Wang,
Yue-Ping Liu,
Yong-Wen Song,
Zhao-Yang Wang,
Qing-Feng Liu,
Hui Fang,
Shu-Nan Qi,
Xin-Fan Liu,
Zi-Hao Yu
et al.
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1115-1121
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Outcomes of Patients With Non-Hodgkin's Lymphoma Treated With Bexxar With or Without External-Beam Radiotherapy
12 May 2011
Purpose: To compare the efficacy and toxicity of external-beam radiotherapy (EBRT) to sites of bulky lymphadenopathy in patients with chemotherapy-refractory low-grade non-Hodgkin’s lymphoma (NHL) imm...
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Kristy Smith,
Gracie Byer,
Christopher G. Morris,
Jessica M. Kirwan,
Judith Lightsey,
Nancy P. Mendenhall,
Bradford S. Hoppe,
James Lynch,
Kenneth Olivier
et al.
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1122-1127
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| Sarcoma |
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Multimodality Local Therapy for Retroperitoneal Sarcoma
09 June 2011
Purpose: Soft-tissue sarcomas of the retroperitoneum are rare tumors comprising less than 1% of all malignancies. Although surgery continues as the mainstay of treatment, the large size of these tumor...
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Nitesh N. Paryani,
Robert A. Zlotecki,
Erika L. Swanson,
Christopher G. Morris,
Stephen R. Grobmyer,
Steven N. Hochwald,
Robert B. Marcus,
Daniel J. Indelicato
et al.
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1128-1134
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| Pediatric Cancers |
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Supratentorial Neurometabolic Alterations in Pediatric Survivors of Posterior Fossa Tumors
09 June 2011
Purpose: Therapy and tumor-related effects such as hypoperfusion, internal hydrocephalus, chemotherapy, and irradiation lead to significant motor and cognitive sequelae in pediatric posterior fossa tu...
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Stefan M. Rueckriegel,
Pablo Hernáiz Driever,
Harald Bruhn
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1135-1141
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Proton Radiotherapy for Pediatric Ewing’s Sarcoma: Initial Clinical Outcomes
19 August 2011
Purpose: Proton radiotherapy (PT) has been prescribed similarly to photon radiotherapy to achieve comparable disease control rates at comparable doses. The chief advantage of protons in this setting i...
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Barbara Rombi,
Thomas F. DeLaney,
Shannon M. MacDonald,
Mary S. Huang,
David H. Ebb,
Norbert J. Liebsch,
Kevin A. Raskin,
Beow Y. Yeap,
Karen J. Marcus,
Nancy J. Tarbell,
Torunn I. Yock
et al.
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1142-1148
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Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study
Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-rela...
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Markhaba Tukenova,
Ibrahima Diallo,
Harald Anderson,
Mike Hawkins,
Stanislaw Garwicz,
Risto Sankila,
Chiraz El Fayech,
Dave Winter,
Carole Rubino,
Elisabeth Adjadj,
Nadia Haddy,
Odile Oberlin,
Torgil Moller,
Froydis Langmark,
Laufey Tryggvadottir,
Hélène Pacquement,
Gudrun Svahn-Tapper,
Florent de Vathaire
et al.
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e383-e390
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| Thoracic Cancers |
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Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review
02 June 2011
Objectives: Patients with severe chronic obstructive pulmonary disease (COPD) have a high risk of lung cancer and of postsurgical complications. We studied outcomes after stereotactic body radiotherap...
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David Palma,
Frank Lagerwaard,
George Rodrigues,
Cornelis Haasbeek,
Suresh Senan
et al.
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1149-1156
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Concurrent Hyperfractionated Radiation Therapy and Chemotherapy in Locally Advanced (Stage III) Non-Small-Cell Lung Cancer: Single Institution Experience With 600 Patients
02 June 2011
Purpose: Our institutional experience with the use of hyperfractionated radiation therapy (RT) alone or concurrently with chemotherapy (RT-CHT) in Stage III non-small-cell lung cancer was reviewed. Me...
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Branislav Jeremić,
Biljana Miličić,
Slobodan Milisavljevic
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1157-1163
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What Is the Best Way to Contour Lung Tumors on PET Scans? Multiobserver Validation of a Gradient-Based Method Using a NSCLC Digital PET Phantom
29 April 2011
Purpose: To evaluate the accuracy and consistency of a gradient-based positron emission tomography (PET) segmentation method, GRADIENT, compared with manual (MANUAL) and constant threshold (THRESHOLD)...
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Maria Werner-Wasik,
Arden D. Nelson,
Walter Choi,
Yoshio Arai,
Peter F. Faulhaber,
Patrick Kang,
Fabio D. Almeida,
Ying Xiao,
Nitin Ohri,
Kristin D. Brockway,
Jonathan W. Piper,
Aaron S. Nelson
et al.
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1164-1171
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Dose Constraints to Prevent Radiation-Induced Brachial Plexopathy in Patients Treated for Lung Cancer
Purpose: As the recommended radiation dose for non-small-cell lung cancer (NSCLC) increases, meeting dose constraints for critical structures like the brachial plexus becomes increasingly challenging,...
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Arya Amini,
Jinzhong Yang,
Ryan Williamson,
Michelle L. McBurney,
Jeremy Erasmus,
Pamela K. Allen,
Mandar Karhade,
Ritsuko Komaki,
Zhongxing Liao,
Daniel Gomez,
James Cox,
Lei Dong,
James Welsh
et al.
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e391-e398
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Quantification of the Variability of Diaphragm Motion and Implications for Treatment Margin Construction
Purpose: To quantify the variability of diaphragm motion during free-breathing radiotherapy of lung patients and its effect on treatment margins to account for geometric uncertainties. Methods and Mat...
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Simon Rit,
Marcel van Herk,
Lambert Zijp,
Jan-Jakob Sonke
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e399-e407
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| Liver Tumors |
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Article Title |
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Pages |
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Usefulness of Positron Emission Tomography With Fluorine-18-Fluorodeoxyglucose in Predicting Treatment Response in Unresectable Hepatocellular Carcinoma Patients Treated With External Beam Radiotherapy
12 May 2011
Purpose: To assess the significance of the ratio between standardized uptake values (SUV) of tumor and normal liver tissue obtained from positron emission tomography with fluorine-18-fluorodeoxyglucos...
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Jun Won Kim,
Jinsil Seong,
Mijin Yun,
Ik Jae Lee,
Hong In Yoon,
Ho Jin Cho,
Kwang-Hyub Han
et al.
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1172-1178
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Peripheral Blood Lymphocyte Depletion After Hepatic Arterial 90Yttrium Microsphere Therapy for Hepatocellular Carcinoma
23 May 2011
Purpose: The short- and long-term effects of 90Yttrium microspheres therapy for hepatocellular carcinoma (HCC) on peripheral blood lymphocytes are unknown and were therefore examined. Methods and Mate...
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Brian I. Carr,
Diana M. Metes
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1179-1184
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| Breast Cancers |
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Article Title |
Author(s) |
Pages |
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Basal Subtype of Invasive Breast Cancer Is Associated With a Higher Risk of True Recurrence After Conventional Breast-Conserving Therapy
20 May 2011
Purpose: To determine whether breast cancer subtype is associated with patterns of ipsilateral breast tumor recurrence (IBTR), either true recurrence (TR) or elsewhere local recurrence (ELR), among wo...
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Jona A. Hattangadi-Gluth,
Jennifer Y. Wo,
Paul L. Nguyen,
Rita F. Abi Raad,
Meera Sreedhara,
Andrzej Niemierko,
Phoebe E. Freer,
Dianne Georgian-Smith,
Jennifer R. Bellon,
Julia S. Wong,
Barbara L. Smith,
Jay R. Harris,
Alphonse G. Taghian
et al.
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1185-1191
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Higher Chest Wall Dose Results in Improved Locoregional Outcome in Patients Receiving Postmastectomy Radiation
25 April 2011
Purpose: Randomized trials demonstrating decreased locoregional recurrence (LRR) and improved overall survival (OS) in women receiving postmastectomy radiation therapy (PMRT) used up to 50 Gy to the c...
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Joseph E. Panoff,
Cristiane Takita,
Judith Hurley,
Isildinha M. Reis,
Wei Zhao,
Steven E. Rodgers,
Vijayalakshmi Gunaseelan,
Jean L. Wright
et al.
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1192-1199
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Impact of Lymph Node Status on Clinical Outcomes After Accelerated Partial Breast Irradiation
22 September 2011
Purpose: To compare outcomes after accelerated partial breast irradiation (APBI) between node-negative and node-positive patients. Methods and Materials: A total of 534 patients with early-stage breas...
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Chirag Shah,
J. Ben Wilkinson,
Simona Shaitelman,
Inga S. Grills,
Peter Y. Chen,
Nayana Dekhne,
Ishmael Jaiyesimi,
Michelle Wallace,
Christina K. Mitchell,
Frank A. Vicini
et al.
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e409-e414
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Prone Hypofractionated Whole-Breast Radiotherapy Without a Boost to the Tumor Bed: Comparable Toxicity of IMRT Versus a 3D Conformal Technique
21 October 2011
Purpose: We report a comparison of the dosimetry and toxicity of three-dimensional conformal radiotherapy (3D-CRT) vs. intensity-modulated radiotherapy (IMRT) among patients treated in the prone posit...
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Matthew E. Hardee,
Shahzad Raza,
Stewart J. Becker,
Gabor Jozsef,
Stella C. Lymberis,
Tsivia Hochman,
Judith D. Goldberg,
Keith J. DeWyngaert,
Silvia C. Formenti
et al.
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e415-e423
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Validating Fiducial Markers for Image-Guided Radiation Therapy for Accelerated Partial Breast Irradiation in Early-Stage Breast Cancer
Purpose: Image-guided radiation therapy (IGRT) may be beneficial for accelerated partial breast irradiation (APBI). The goal was to validate the use of intraparenchymal textured gold fiducials in pati...
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Catherine K. Park,
Jakub Pritz,
Geoffrey G. Zhang,
Kenneth M. Forster,
Eleanor E.R. Harris
et al.
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e425-e431
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| Genitourinary Cancers |
| |
Article Title |
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Later Outcomes and Alpha/Beta Estimate From Hypofractionated Conformal Three-Dimensional Radiotherapy Versus Standard Fractionation for Localized Prostate Cancer
07 April 2011
Purpose: Now that the follow-up time has exceeded 5 years, an estimate of the α/β ratio can be presented. The additional late outcomes in patients treated with three-dimensional conformal external bea...
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Felix Leborgne,
Jack Fowler,
José H. Leborgne,
Julieta Mezzera
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1200-1207
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Role of Intra- or Periprostatic Calcifications in Image-Guided Radiotherapy for Prostate Cancer
02 June 2011
Purpose: Image-guided radiotherapy (IGRT) allows more precise localization of the prostate, thus minimizing errors resulting from organ motion and set-up during treatment of prostate cancer. Using meg...
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Samir Abdallah Hanna,
Wellington Furtado Pimenta Neves-Junior,
Gustavo Nader Marta,
Cecília Maria Kalil Haddad,
João Luis Fernandes da Silva
et al.
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1208-1216
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Prostate-Specific Antigen Velocity Before and After Elimination of Factors That Can Confound the Prostate-Specific Antigen Level
02 June 2011
Purpose: Prostate-specific antigen (PSA) velocity, like PSA level, can be confounded. In this study, we estimated the impact that confounding factors could have on correctly identifying a patient with...
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Jessica J. Park,
Ming-Hui Chen,
Marian Loffredo,
Anthony V. D’Amico
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1217-1221
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Proton Radiotherapy for Prostate Cancer Is Not Associated With Post-Treatment Testosterone Suppression
12 May 2011
Purpose: Three independent studies of photon (x-ray) radiotherapy (RT) for prostate cancer have demonstrated evidence of testosterone suppression after treatment. The present study was undertaken to d...
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R. Charles Nichols,
Christopher G. Morris,
Bradford S. Hoppe,
Randal H. Henderson,
Robert B. Marcus,
William M. Mendenhall,
Zuofeng Li,
Christopher R. Williams,
Joseph A. Costa,
Nancy P. Mendenhall
et al.
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1222-1226
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Concurrent Androgen Deprivation Therapy During Salvage Prostate Radiotherapy Improves Treatment Outcomes in High-Risk Patients
06 May 2011
Purpose: To determine whether concurrent androgen deprivation therapy (ADT) during salvage radiotherapy (RT) improves prostate cancer treatment outcomes. Methods and Materials: A total of 630 postpros...
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Daniel E. Soto,
Michael N. Passarelli,
Stephanie Daignault,
Howard M. Sandler
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1227-1232
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The Benefits of Including Clinical Factors in Rectal Normal Tissue Complication Probability Modeling After Radiotherapy for Prostate Cancer
09 June 2011
Purpose: To study the impact of clinical predisposing factors on rectal normal tissue complication probability modeling using the updated results of the Dutch prostate dose-escalation trial. Methods a...
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Gilles Defraene,
Laura Van den Bergh,
Abrahim Al-Mamgani,
Karin Haustermans,
Wilma Heemsbergen,
Frank Van den Heuvel,
Joos V. Lebesque
et al.
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1233-1242
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Castration Therapy of Prostate Cancer Results in Downregulation of HIF-1α Levels
Background and Purpose: Neoadjuvant androgen deprivation in combination with radiotherapy of prostate cancer is used to improve radioresponsiveness and local tumor control. Currently, the underlying m...
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Firas L.T. Al-Ubaidi,
Niklas Schultz,
Lars Egevad,
Torvald Granfors,
Thomas Helleday
et al.
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1243-1248
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Hypoxic Prostate/Muscle Po2 Ratio Predicts for Outcome in Patients With Localized Prostate Cancer: Long-Term Results
10 October 2011
Purpose: To correlate tumor oxygenation status with long-term biochemical outcome after prostate brachytherapy. Methods and Materials: Custom-made Eppendorf Po2 microelectrodes were used to obtain Po2...
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Aruna Turaka,
Mark K. Buyyounouski,
Alexandra L. Hanlon,
Eric M. Horwitz,
Richard E. Greenberg,
Benjamin Movsas
et al.
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e433-e439
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Pathological Predictors for Site of Local Recurrence After Radiotherapy for Prostate Cancer
Purpose: Rational design of targeted radiotherapy (RT) in prostate cancer (Pca) hinges on a better understanding of spatial patterns of recurrence. We sought to identify pathological factors predictiv...
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Supriya Chopra,
Ants Toi,
Nathan Taback,
Andrew Evans,
Masoom A. Haider,
Michael Milosevic,
Robert G. Bristow,
Peter Chung,
Andrew Bayley,
Gerard Morton,
Danny Vesprini,
Padraig Warde,
Charles Catton,
Cynthia Ménard
et al.
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e441-e448
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20 Gy Versus 44 Gy of Supplemental External Beam Radiotherapy With Palladium-103 for Patients With Greater Risk Disease: Results of a Prospective Randomized Trial
22 December 2011
Purpose: The necessity of external beam radiotherapy (EBRT) as a supplement to prostate brachytherapy remains unknown. We report brachytherapy outcomes for patients with higher risk features randomize...
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Gregory S. Merrick,
Kent E. Wallner,
Wayne M. Butler,
Robert W. Galbreath,
Al V. Taira,
Peter Orio,
Edward Adamovich
et al.
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e449-e455
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Whole-Pelvis or Bladder-Only Chemoradiation for Lymph Node–Negative Invasive Bladder Cancer: Single-Institution Experience
23 September 2011
Purpose: Whole-pelvis (WP) concurrent chemoradiation (CCRT) is the standard bladder preserving option for patients with invasive bladder cancer. The standard practice is to treat elective pelvic lymph...
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Mutahir A. Tunio,
Altaf Hashmi,
Abdul Qayyum,
Rehan Mohsin,
Ahmed Zaeem
et al.
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e457-e462
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Type of Diabetes Mellitus and the Odds of Gleason Score 8 to 10 Prostate Cancer
22 September 2011
Purpose: It has been recently shown that diabetes mellitus (DM) is significantly associated with the likelihood of presenting with high-grade prostate cancer (PCa) or Gleason score (GS) 8 to 10; howev...
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Josephine Kang,
Ming-Hui Chen,
Yuanye Zhang,
Brian J. Moran,
Daniel E. Dosoretz,
Michael J. Katin,
Michelle H. Braccioforte,
Sharon A. Salenius,
Anthony V. D'Amico
et al.
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e463-e467
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External-Beam Radiation Therapy and High–Dose Rate Brachytherapy Combined With Long-Term Androgen Deprivation Therapy in High and Very High Prostate Cancer: Preliminary Data on Clinical Outcome
Purpose: To determine the feasibility of combined long-term androgen deprivation therapy (ADT) and dose escalation with high-dose-rate (HDR) brachytherapy. Methods and Materials: Between 2001 and 2007...
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Rafael Martínez-Monge,
Marta Moreno,
Raquel Ciérvide,
Mauricio Cambeiro,
José Luis Pérez-Gracia,
Ignacio Gil-Bazo,
Miren Gaztañaga,
Leire Arbea,
Ignacio Pascual,
Javier Aristu
et al.
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e469-e476
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| Gynecologic Cancers |
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External Pelvic and Vaginal Irradiation Versus Vaginal Irradiation Alone as Postoperative Therapy in Medium-Risk Endometrial Carcinoma—A Prospective Randomized Study
14 June 2011
Purpose: To evaluate the value of adjuvant external beam pelvic radiotherapy as adjunct to vaginal brachytherapy (VBT) in medium-risk endometrial carcinoma, with regard to locoregional tumor control, ...
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Bengt Sorbe,
György Horvath,
Håkan Andersson,
Karin Boman,
Caroline Lundgren,
Birgitta Pettersson
et al.
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1249-1255
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Continuous 7-Days-A-Week External Beam Irradiation in Locally Advanced Cervical Cancer: Final Results of the Phase I/II Study
12 May 2011
Purpose: To evaluate the feasibility and efficacy of definitive continuous 7-days-a-week pelvic irradiation without breaks between external beam radiotherapy and brachytherapy in locally advanced cerv...
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Krystyna Serkies,
Rafał Dziadziuszko,
Jacek Jassem
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1256-1261
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Dosimetric Comparison of Combined Intensity-Modulated Radiotherapy (IMRT) and Proton Therapy Versus IMRT Alone for Pelvic and Para-Aortic Radiotherapy in Gynecologic Malignancies
16 December 2011
Purpose: To perform a dosimetric comparison of intensity-modulated radiotherapy (IMRT), passive scattering proton therapy (PSPT), and intensity-modulated proton therapy (IMPT) to the para-aortic (PA) ...
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Abigail Berman Milby,
Stefan Both,
Mark Ingram,
Lilie L. Lin
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e477-e484
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Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance
18 October 2011
Purpose: To systematically screen the tumor contrast enhancement of locally advanced cervical cancers to assess the prognostic value of two descriptive parameters derived from dynamic contrast-enhance...
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Erlend K.F. Andersen,
Knut Håkon Hole,
Kjersti V. Lund,
Kolbein Sundfør,
Gunnar B. Kristensen,
Heidi Lyng,
Eirik Malinen
et al.
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e485-e492
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| Central Nervous System |
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Tumor Shrinkage Assessed by Volumetric MRI in Long-Term Follow-Up After Fractionated Stereotactic Radiotherapy of Nonfunctioning Pituitary Adenoma
29 April 2011
Purpose: To evaluate tumor control and side effects associated with fractionated stereotactic radiotherapy (FSRT) in the management of residual or recurrent nonfunctioning pituitary adenomas (NFPAs). ...
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Christine Kopp,
Marilena Theodorou,
Nektarios Poullos,
Vesna Jacob,
Sabrina T. Astner,
Michael Molls,
Anca-Ligia Grosu
et al.
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1262-1267
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Standard-Fractionated Radiotherapy for Optic Nerve Sheath Meningioma: Visual Outcome Is Predicted by Mean Eye Dose
02 June 2011
Purpose: Radiotherapy has shown its efficacy in controlling optic nerve sheath meningiomas (ONSM) tumor growth while allowing visual acuity to improve or stabilize. However, radiation-induced toxicity...
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Lucie Abouaf,
Nicolas Girard,
Thibaud Lefort,
Anne D’hombres,
Caroline Tilikete,
Alain Vighetto,
Françoise Mornex
et al.
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1268-1277
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Volumetric Modulated Arc–Based Hypofractionated Stereotactic Radiotherapy for the Treatment of Selected Intracranial Arteriovenous Malformations: Dosimetric Report and Early Clinical Experience
13 April 2011
Purpose: To evaluate, with a dosimetric and clinical feasibility study, RapidArc (a volumetric modulated arc technique) for hypofractionated stereotactic radiotherapy treatment of large arteriovenous ...
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Sai Subramanian,
Chilukuri Srinivas,
K. Ramalingam,
M. Babaiah,
S. Thirumalai Swamy,
G. Arun,
M. Kathirvel,
S. Ashok,
Alessandro Clivio,
Antonella Fogliata,
Giorgia Nicolini,
K. Srinivasa Rao,
T. Pratap Reddy,
Jotwani Amit,
Eugenio Vanetti,
Luca Cozzi
et al.
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1278-1284
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